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Ibuprofen/Probiotic Study Receive $1200 — $1200

This study is investigating the possible positive effect of a probiotic against…


Ibuprofen/Probiotic Study Receive $1200
Non-Steroidal-Anti-Inflammatory Drugs (NSAIDs), such as Ibuprofen, are commonly used worldwide, both as prescription-only medicines and as “over-the-counter” medications. They are often used in the treatment of many common pain-related conditions, including headaches and menstrual pain, and for long-term treatment of chronic inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Long-term use of low-dose NSAIDS are also recommended and prescribed for their heart-protecting properties.

However, low dose use of NSAIDS, such as ibuprofen, is associated with damage to the stomach and intestines.

Live bacteria formulated as probiotics may offer a safe alternative to prevent negative side effects of NSAIDS, such as ibuprofen. Probiotic bacteria have been demonstrated to have possible healing effects against intestinal inflammation among long-term ibuprofen users.

The goal of this study is to explore the ability of a probiotic to reduce and/or reverse ibuprofen-induced small intestinal damage and GI symptoms in healthy volunteers.

The study includes a run-in period lasting up to two-weeks, followed by a six-week intervention period where a dose of probiotic or placebo is taken daily, along with ibuprofen. The study Involves a screening visit and 6 subsequent visits to the study site.

At each of the 6 visits, we will measure the ibuprofen damage to your intestine using Video Capsule Endoscopy (VCE). Capsule endoscopy uses a tiny wireless camera which sits inside a vitamin-size capsule you swallow. As the capsule travels through your digestive tract, the camera takes thousands of pictures that are transmitted to a recorder you wear on a belt around your waist. The capsule is excreted after about 8-12 hours We will also collect some blood and stool samples as well as some demographic and general health data at each visit.
Please note: You must return the recorder back to the clinic after your visit, later in the day.

You will receive $1200 for your time upon completion of the trial.

Compensation

You will receive $1200 for your time upon completion of the trial.

Register Now!

To register for this study, you will need take a brief eligibility questionnaire and to provide your contact information. If you are registering on behalf of someone else, you will still be listed as the primary contact.

Reason for Interest

Briefly describe the reason the participant is interested in this study and why the participant should be considered eligible for participation.

Eligibility Questionnaire

Your answers to the questions below will be provided to the researcher to help determine eligibility for this study.

1. Are you Between the Ages of 18-40?

 
 

2. Are you currently taking any medications? (oral contraceptive + inhalers do not count as medication for this)

 
 

3. Do you smoke or use nicotine products (Vape/juul)?

 
 

4. Do you take/consume probiotics regularly?

 
 
 

5. Do you have any underlying health conditions?

 
 

6. Have you used Antibiotics in the past 6 weeks?

 
 

Contact Information

Demographic Information

Your gender and birthday are used to help determine eligibility for this study. The researcher will be provided with your gender and age (in years).

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